Role of weight-loss associated miRNA, MYLIP and CETP in adipocyte dysfunction and maladaptive adipocyte macrophage cross-talk
Prof. Dr. Berend Isermann
Obesity triggers chronic low-grade inflammation, an immune response which is characterized by adipose tissue inflammation and adipose tissue macrophage accumulation. Evidence suggests that obesity associated maladaptive adipocyte-macrophage interaction promotes adipose tissue dysfunction, insulin resistance and increased risk for metabolic syndrome (MetS) that is a precursor for type 2 diabetes and cardiovascular disease (CVD). Interestingly, lifestyle-induced weight loss is regarded as an efficient therapy to reverse the adipose tissue dysfunction and to prevent progression to type 2 diabetes and associated CVD. However, molecular insights into pathways that promote reversibility of adipose tissue dysfunction remain scarce so far.