RTG 2408 - Maladaptive processes across physiological barriers in chronic diseases

Associated Project 3

Role of weight-loss associated miRNA, MYLIP and CETP in adipocyte dysfunction and maladaptive adipocyte macrophage cross-talk

 

ZL2

Zhen Li

PhD Student

                                

BI2

Prof. Dr. Berend Isermann

Project Leader

Obesity triggers chronic low-grade inflammation, an immune response which is characterized by adipose tissue inflammation and adipose tissue macrophage accumulation. Evidence suggests that obesity associated maladaptive adipocyte-macrophage interaction promotes adipose tissue dysfunction, insulin resistance and increased risk for metabolic syndrome (MetS) that is a precursor for type 2 diabetes and cardiovascular disease (CVD). Interestingly, lifestyle-induced weight loss is regarded as an efficient therapy to reverse the adipose tissue dysfunction and to prevent progression to type 2 diabetes and associated CVD. However, molecular insights into pathways that promote reversibility of adipose tissue dysfunction remain scarce so far.


In our study, we found that lifestyle-induced weight loss was associated with substantial improvement of insulin sensitivity, systemic low-grade inflammation and lipid metabolism, resulting in reversibility of the MetS. The effect of lifestyle-induced weight loss therapy on subcutaneous adipose tissue specific microRNA (miR) and RNA expression was investigated. Lifestyle-induced weight loss was found to be associated with specific alterations of adipocyte and macrophage specific genes. The aim of the proposed study is to investigate interplay of identified genes to identify potential therapeutic target for patients with MetS.

 AP03

 

 

upPhotos: M. Dybiona/University Hospital Magdeburg

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