RTG 2408 - Maladaptive processes across physiological barriers in chronic diseases


in press

Wackernagel L-M, Abdi Sarabi M, Weinert S, Zuschratter W, Richter K, Fischer KD, Braun-Dullaeus R, Medunjanin S. 2022 IKKγ/NEMO localization into multivesicular bodies. Int J Mol Sci. IF: 6,1 (accepted) LINK

Aghapour M, Surender S, Bruder D. 2022 Beware the intruder: gasodermin A as molecular guardian preventing systemic dissemination of group A streptococci following local skin infection. Cell Mol Immunol. IF: 11,530 PMID: 35414713.



Aghapour M, Ubags ND, Bruder D, Hiemstra PS, Sidhaye V, Rezaee F, Heijink IH. 2022 Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. Eur Respir Rev. 31:210112 IF: 8,839 PMID: 35321933

Aghapour M, Tulen CBM, Abdi Sarabi M, Weinert S, Müsken M, Relja B, van Schooten F-J, Jeron A, Braun-Dullaeus RC, Remels AH, Bruder D. Cigarette smoke extract disturbs mitochondria-regulated air-way epithelial cell responses to pneumococci. Cells. 11:1771. IF: 6,600 PMID: 35681466

Ambreen S, Fatima S, Elwakiel A, Rana R, Singh K, Gupta A, Gupta D, Khawaja H, Manoharan J, Besler C, Laufs U, Kohli S, Isermann B, Shahzad K. Hypercoagulability impairs plaque stability in diabetes-induced atherosclerosis. Nutrients. 14:1991. IF:5.719 PMID:35631132.

Chaithongyot S, Naumann M. 2022 Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell-death. Cell Mol Life Sci. 79:86 IF: 9,261 PMID: 35066747.

Gelmez E, Jeron A, Bruder D. 2022 Negative elongation factor: a key factor in the maintenance of intestinal epithelial barrier integrity. Cell Mol Immunol. 19:453-455. IF: 11,530. PMID: 34992279

Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, Thurm C, Negele J, Franz T, Stegemann-Koniszewski S, Schreiber J, Shukla A, Geffers R, Schraven B, Reinhold D, Dudeck A, Reinhold A, Müller A, Kahlfuss S. 2022 Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc. Sci Rep. 12:1943 IF: 4,380 PMID: 35121767.

Noack L, Xu B, Bundkirchen K, Zhou Y, Köhler K, Jantaree P, Neunaber C, Nowak A, Relja B. 2022 Acute intoxication with alcohol reduces trauma-induced proinflammatory response and barrier breakdown in the lung via Wnt/ß-catenin signaling pathway. Front Immunol. 13:866925 IF: 7,561 PMID: 35663960

Ragipoglu D, Bülow J, Hauff K, Voss M, Haffner-Luntzer M, Dudeck A, Ignatius A, Fischer V. 2022 Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma. Front Immunol. 13:883707. IF: 7,561 PMID: 35558068.



Bakhchova L, Jantaree P, Gupta A, Isermann B, Steinmann U, Naumann M. 2021 On-a-chip based sensitive detection of drug-induced apoptosis in polarized gastric epithelial cells. ACS Biomater Sci Eng. 7:5474-5483. IF: 4,749 PMID: 34704732

Bernhardt A, Häberer S, Xu J, Damerau H, Steffen J, Reichardt C, Wolters K, Steffen H, Isermann B, Borucki K, Artelt N, Endlich N, Kozyraki R, Brandt S, Lindquist JA, Mertens PR. 2021. High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1. FASEB J. 35:e21912. IF: 5,191 PMID: 34533842 

Bollmann M, Pinno K, Ehnold LI, Märtens N, Märtson A, Pap T, Stärke C, Lohmann CH, Bertrand J. 2021. MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity. Osteoarthr Cartil. 29:280-289. IF: 6,576  PMID: 33246160

Chaithongyot SJantaree P, O Sokolova, Naumann M. 2021. NF-kB in gastric cancer development and therapy. Biomedicines. 9:870. IF: 6,081 PMID: 34440074

Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. 2021. Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation. Immunity. 54:468-483.e5. IF: 31,745 PMID: 33484643

Gadi I, Fatima S, Elwakiel A, Nazir S, Al-Dabet MM, Rana R, Bock F, Manhoran J, Gupta D, Biemann R, Nieswand B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH,  Esmon CT, Kohli S, Isermann BShahzad K. 2021. Different DOACs control inflammation in cardiac ischemia-reperfusion differently. Circs Res128:513-529. IF: 15,862 PMID:33353373

Jantaree P, L Bakhchova, U Steinmann, M Naumann. 2021. From 3D back to 2D monolayer stomach organoids-on-a-chip. Trends Biotechnol. 39:745-748. IF: 19,536 PMID:33353764

Kohli S, KK Singh, A Gupta, P Markmeyer, F Lochmann, D Gupta, R Rana, A Elwakiel, H Huebner, M Ruebner, B Isermann. 2021. Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression. Blood. 137:977-982. IF: 17,543 PMID:32870264

Mougiakakos DKahlfuss S. 2021. "Moonlighting" at the power plant: how mitochondria facilitate serial killing by CD8+ cytotoxic T cells. Signal Transduct Target Ther. 6:436. IF: 18,187 PMID: 34937859

Shahzad K, Fatima S, Al-Dabet MM, Gadi I, Khawaja H, Ambreen S, Elwakiel A, Klöting N, Blüher M, Nawroth PP, Mertens PR, Michel S, Jaschinski F, Klar R, Isermann B. 2021. CHOP-ASO ameliorates glomerular and tubular damage on top of ACE inhibition in diabetic kidney disease. J Am Soc Nephrol. 32:3066-3079. IF: 10,121 PMID: 34479965.

Voss M, J Kotrba, E Gaffal, K Katsoulis-Dimitriou, A Dudeck. 2021. Mast cells in the skin: defenders of integrity or offenders in inflammation? Int J Mol Sci. 22:4589. IF: 4,556 PMID:33925601

Zimmermann S, Costa MBW, Mathew A, Krishnan S, Schneider JG, Roomp K, Isermann B, Biemann R. 2021. Osteocalcin is independently associated with C-reactive protein during lifestyle-induced weight loss in metabolic syndrome. Metabolites. 11:526. IF: 4,754 PMID: 34436467



Aghapour M., Remels A. H.V., Pouwels S.D., Bruder D., Hiemstra P.S., Cloonan S.M., Heijink I.H. 2020. Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 318:L149-L164. IF: 3,78 PMID:31693390

Dubiel W, S Chaithongyot, D Dubiel, M Naumann. 2020. The COP9 signalosome: a multi-DUB complex. Biomolecules 10:1082. IF: 4,082 PMID:32708147

Jorde I, CB Hildebrand, O Kershaw, E Lücke, S Stegemann-Koniszewski, J Schreiber. 2020. Modulation of allergic sensitization and allergic inflammation by staphylococcus aureus enterotoxin b in an ovalbumin mouse modul. Front Immunol. 11:592186. IF: 5,085 PMID:33193436

Katsoulis-Dimitriou K, J Kotrba, M Voss, J Dudeck, A Dudeck. 2020. Mast cell functions linking innate sensing to adaptive immunity. Cells. 9:2538. IF: 4,366 PMID:33255519

Madhusudhan T, S Ghosh, H Wang, W Dong, D Gupta, A Elwakiel, S Stoyanov, MM Al-Dabet, S Krishnan, R Biemann, S Nazir, S ZimmermannA Mathew, I Gadi, R Rana, J Zeng-Brouwers, MJ Moeller, L Schaefer, CT Esmon, S Kohli, J Reiser, AR Rezaie, W Ruf, B Isermann. 2020. Podocyte integrin-β3 and activated protein C coordinately restrict RhoA signaling and ameliorate diabetic nephropathy. J Am Soc Nephrol. 31:1762-1780. IF: 9,274 PMID:32709711

Morgenroth RC Reichardt, J Steffen, S Busse, R Frank, H Heidecke, PR Mertens. 2020. Autoantibody formation and mapping of immunogenic epitopes against cold-shock-protein-YB-1 in cancer patients and healthy controls. Cancers. 12:3507. IF: 6,126 PMID:33255653

Nowak A, B Relja. 2020. The impact of acute or chronic alcohol intake on the NF-κB signaling pathway in alcohol-related liver disease. Int J Mol Sci. 21:9407. IF: 4,556 PMID:33321885

Wu Q, I Jorde, O Kershaw, A Jeron, D Bruder, J Schreiber, S Stegemann-Koniszewski. 2020. Resolved influenza a virus infection has extended effects on lung homeostasis and attenuates allergic airway inflammation in a mouse model. Microorganisms. 8:1878. IF: 4,167 PMID:33260910

Xu B, A Chandrasekar, F Olde Heuvel, M Powerski, A NowakL Noack, J Omari, M Huber-Lang, F Roselli, B Relja. 2020. Ethanol intoxication alleviates the inflammatory response of remote organs to experimental traumatic brain injury. Int J Mol Sci. 21:8181. IF: 4,556 PMID:33142949



Brandt S, L Ewert, FG Scurt, C Reichardt, JA Lindquist, X Gorny, B Isermann, PR Mertens. 2019. Altered monocytic phenotypes are linked with systemic inflammation and may be linked to mortality in dialysis patients. Sci Rep. 9:19103. IF: 3,998 PMID:31836803


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