RTG 2408 - Maladaptive processes across physiological barriers in chronic diseases






Baars I, Jaedtka M, Dewitz LA, Fu Y, Franz T, Mohr J, Gintschel P, Berlin H, Degen A, Freier S, Rygol S, Schraven B, Kahlfuß S, van Zandbergen G, & Müller AJ. 2023. Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate. JCI Insight. 8:e169020. IF: 8,000 PMID: 37310793

Bernhardt A, Krause A, Reichardt C, Steffen H, Isermann B, Völker U, Hammer E, Geffers R, Phillipsen L, Dhjamandi K, Ahmad S, Brandt S, Lindquist JA, Mertens PR. 2023. Excessive sodium chloride ingestion promotes inflammation and kidney fibrosis in aging mice. Am J Physiol Cell Physiol. 325:C456-C470. IF: 5,500  PMID: 37399499

Dubiel D, Wang J, Hartig R, Chaithongyot S, Dubiel W,  Naumann M. 2023. Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18. iScience. 26:106468. IF: 5,800 PMID: 37091236

Krishnan S, Manoharan J, Wang H, Gupta D, Fatima S, Yu Y, Mathew A, Li Z, Kohli S, Schwab C, Körner A, Mertens PR, Nawroth P, Shahzad K, Naumann M, Isermann B, Biemann R. 2023. CD248 induces maladaptive unfolded protein response in diabetic kidney disease. Kidney Int. 103:304-319. IF: 19,600 PMID: 36309126

Lim MCC, Jantaree P, Naumann M. 2023. The conundrum of Helicobacter pylori-associated apoptosis in gastric cancer. Trends Cancer. 9:679-690. IF: 18,400 PMID: 37230895

Lindquist JA, Bernhardt A, Reichardt C, Sauter E, Brandt S, Rana R, Lindenmeyer MT, Philipsen L, Isermann B, Zhu C, Mertens PR. 2023. Cold shock domain protein DbpA orchestrates tubular cell damage and interstitial fibrosis in inflammatory kidney disease. Cells. 12:1426. IF: 6,000 PMID: 37408260

Naumann M, Ferino L, Sharafutdinov I, Backert S. 2023. Gastric epithelial barrier disruption, inflammation and oncogenic signal transduction by Helicobacter pylori. Curr Top Microbiol Immunol. 444:207-238. IF: 4,300 PMID: 38231220

Nöthen T, Abdi Sarabi M, Weinert S, Zuschratter W, Morgenroth R, Mertens PR, Braun-Dullaeus RC, Medunjanin S. 2023. DNA-dependent protein kinase mediates YB-1-induced DSB repair. Arterioscler Thromb Vasc Biol. 43:300-311. IF: 8,700 PMID:36475703 



Abdi Sarabi M, Shiri A, Aghapour M, Reichardt C, Brandt S, Mertens PR, Medunjanin S, Bruder D; Braun-Dullaeus RC; Weinert S. 2022. Normoxic HIF-1α stabilization caused by local inflammatory factors and its consequences in human coronary artery endothelial cells. Cells. IF: 7,666 PMID: 36497143

Aghapour M, Surender S, Bruder D. 2022. Beware the intruder: gasodermin A as molecular guardian preventing systemic dissemination of group A streptococci following local skin infection. Cell Mol Immunol. 19:761-763 IF: 22,096 PMID: 35414713

Aghapour M, Tulen CBM, Abdi Sarabi M, Weinert S, Müsken M, Relja B, van Schooten F-J, Jeron A, Braun-Dullaeus RC, Remels AH, Bruder D. 2022. Cigarette smoke extract disturbs mitochondria-regulated air-way epithelial cell responses to pneumococci. Cells. 11:1771. IF: 7,666 PMID: 35681466

Aghapour M, Ubags ND, Bruder D, Hiemstra PS, Sidhaye V, Rezaee F, Heijink IH. 2022. Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. Eur Respir Rev. 31:210112 IF: 9,553 PMID: 35321933

Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B. 2022. Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression. Nat Commun. 13:5062. IF: 17.694 PMID: 36030260

Ambreen S, Fatima S, Elwakiel A, Rana R, Singh K, Gupta A, Gupta D, Khawaja H, Manoharan J, Besler C, Laufs U, Kohli S, Isermann B, Shahzad K. 2022. Hypercoagulability impairs plaque stability in diabetes-induced atherosclerosis. Nutrients. 14:1991. IF: 6,706 PMID:35631132

Chaithongyot S, Naumann M. 2022. Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell-death. Cell Mol Life Sci. 79:86 IF: 9,237 PMID: 35066747

Fatima S, Ambreen S, Mathew A, Elwakiel A, Gupta A, Singh K, Krishnan S, Rana R, Khawaja H, Gupta D, Manoharan J, Besler C, Laufs U, Kohli S, Isermann B, Shahzad K. 2022. ER-stress and senescence coordinately promote endothelial barrier dysfunction in diabetes-induced atherosclerosis. Nutrients. 14:2786. IF: 6,706 PMID: 35889743

Franz T, Negele J, Bruno P, Böttcher M, Mitchell-Flack M, Reemts L, Krone A, Mougiakakos D, Müller AJ, Zautner AE, Kahlfuss S. 2022. Pleiotropic effects of antibiotics on T cell metabolism and T cell-mediated immunity. Front Microbiol. IF: 6.064 PMID: 36329851

Franz T, Negele J, Kahlfuss S. 2022. Cytotoxic innate lymphoid cells sense tumor-derived IL-15: a novel mechanism of cancer immunosurveillance. Signal Transduct Target Ther. 7:326 IF: 38,126 PMID: 36115839

Gaul S, Shahzad K, Medert R, Gadi I, Mäder C, Schumacher D, Wirth A, Ambreen S, Fatima S, Boeckel JN, Khawaja H, Haas J, Brune M, Nawroth PP, Isermann B, Laufs U, Freichel M. 2022. Novel nongenetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosis. Front Cardiovasc Med. 9:813215. IF: 5.846 PMID: 35350534

Gelmez E, Jeron A, Bruder D. 2022 Negative elongation factor: a key factor in the maintenance of intestinal epithelial barrier integrity. Cell Mol Immunol. 19:453-455. IF: 22,096. PMID: 34992279

Gelmez E, Lehr K, Kershaw O, Frentzel S, Vilchez-Vargas R, Bank U, Link A, Schüler T, Jeron A, Bruder D. 2022. Characterization of maladaptive processes in acute, chronic and remission phases of experimental colitis in C57BL/6 mice. Biomedicines10:1903 IF: 4,757 PMID: 36009449

Gupta A, Singh K, Fatima S, Ambreen S, Zimmermann S, Younis R, Krishnan S, Rana R, Gadi I, Schwab C, Biemann R, Shahzad K, Rani V, Ali S, Mertens PR, Kohli S, Isermann B. 2022. Neutrophil extracellular traps promote NLRP3 inflammasome activation and glomerular endothelial dysfunction in diabetic kidney disease. Nutrients. 14:2965. IF: 6,706 PMID: 35889923

Jantaree P, Chaithongyot S, Sokolova O, Naumann M. 2022. USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection. Cell Mol Life Sci. 79:461 IF: 9,237 PMID: 35913642

Jantaree P, Yu Y, Chaithongyot S, Täger T, Abdi Sarabi M, Meyer TF, Boccellato F, Maubach G, Naumann M. 2022. Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori. Biochim Biophys Acta–Mol Cell Res. 1869:119364. IF: 5.011 PMID: 36162648

Krone A, Fu Y, Schreiber S, Kotrba J, Borde L, Nötzold A, Thurm C, Negele J, Franz T, Stegemann-Koniszewski S, Schreiber J, Shukla A, Geffers R, Schraven B, Reinhold D, Dudeck A, Reinhold A, Müller A, Kahlfuss S. 2022. Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc. Sci Rep. 12:1943 IF: 4,996 PMID: 35121767

Noack L, Xu B, Bundkirchen K, Zhou Y, Köhler K, Jantaree P, Neunaber C, Nowak A, Relja B. 2022. Acute intoxication with alcohol reduces trauma-induced proinflammatory response and barrier breakdown in the lung via Wnt/ß-catenin signaling pathway. Front Immunol. 13:866925 IF: 8,786 PMID: 35663960

Ragipoglu D, Bülow J, Hauff K, Voss M, Haffner-Luntzer M, Dudeck A, Ignatius A, Fischer V. 2022. Mast cells drive systemic inflammation and compromised bone repair after trauma. Front Immunol. 13:883707. IF: 8,786 PMID: 35558068

Rana R, Manoharan J, Gupta A, Gupta D, Elwakiel A, Khawaja H, Fatima S, Zimmermann S, Singh K, Ambreen S, Gadi I, Biemann R, Jiang S, Shahzad K, Kohli S, Isermann B. 2022. Activated protein C ameliorates tubular mitochondrial reactive oxygen species and inflammation in diabetic kidney disease. Nutrients. 14:3138. IF: 6,706 PMID: 35956315

Roder M, Kahlfuss S. 2022. Implementation of immunometabolism into curricula, scientific societies, and immunological routine diagnostics. J Immunological Sci. 6:18-21 LINK

Shahzad K, Fatima S, Khawaja H, Elwakiel A, Gadi I, Ambreen S, Zimmermann S, Mertens PR, Biemann R, Isermann B. 2022. Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease. Kidney Int. 102:766-779 IF: 18,998 PMID: 35779608

Wackernagel L-M, Abdi Sarabi M, Weinert S, Zuschratter W, Richter K, Fischer KD, Braun-Dullaeus R, Medunjanin S. 2022. IKKγ/NEMO localization into multivesicular bodies. Int J Mol Sci. 23:6778 IF: 6,208 PMID:35743220

Zimmermann S, Vogel M, Mathew A, Ebert T, Rana R, Jiang S, Isermann B, Biemann R. 2022. The extent of lifestyle-induced weight loss determines the risk of prediabetes and metabolic syndrome recurrence during a 5-year follow-up. Nutrients. 14:3060. IF: 6,706 PMID: 35893913



Bakhchova L, Jantaree P, Gupta A, Isermann B, Steinmann U, Naumann M. 2021 On-a-chip based sensitive detection of drug-induced apoptosis in polarized gastric epithelial cells. ACS Biomater Sci Eng. 7:5474-5483. IF: 4,749 PMID: 34704732

Bernhardt A, Häberer S, Xu J, Damerau H, Steffen J, Reichardt C, Wolters K, Steffen H, Isermann B, Borucki K, Artelt N, Endlich N, Kozyraki R, Brandt S, Lindquist JA, Mertens PR. 2021. High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1. FASEB J. 35:e21912. IF: 5,191 PMID: 34533842 

Bollmann M, Pinno K, Ehnold LI, Märtens N, Märtson A, Pap T, Stärke C, Lohmann CH, Bertrand J. 2021. MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity. Osteoarthr Cartil. 29:280-289. IF: 6,576  PMID: 33246160

Chaithongyot SJantaree P, Sokolova O, Naumann M. 2021. NF-kB in gastric cancer development and therapy. Biomedicines. 9:870. IF: 6,081 PMID: 34440074

Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. 2021. Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation. Immunity. 54:468-483.e5. IF: 31,745 PMID: 33484643

Gadi I, Fatima S, Elwakiel A, Nazir S, Al-Dabet MM, Rana R, Bock F, Manhoran J, Gupta D, Biemann R, Nieswand B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH,  Esmon CT, Kohli S, Isermann BShahzad K. 2021. Different DOACs control inflammation in cardiac ischemia-reperfusion differently. Circs Res128:513-529. IF: 15,862 PMID:33353373

Jantaree P, Bakhchova L, Steinmann U, Naumann M. 2021. From 3D back to 2D monolayer stomach organoids-on-a-chip. Trends Biotechnol. 39:745-748. IF: 19,536 PMID:33353764

Kohli S, Singh KK, Gupta A, Markmeyer P, Lochmann F, Gupta D, Rana, Elwakiel A, Huebner H, Ruebner M, Isermann B. 2021. Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression. Blood. 137:977-982. IF: 17,543 PMID:32870264

Shahzad K, Fatima S, Al-Dabet MM, Gadi I, Khawaja H, Ambreen S, Elwakiel A, Klöting N, Blüher M, Nawroth PP, Mertens PR, Michel S, Jaschinski F, Klar R, Isermann B. 2021. CHOP-ASO ameliorates glomerular and tubular damage on top of ACE inhibition in diabetic kidney disease. J Am Soc Nephrol. 32:3066-3079. IF: 10,121 PMID: 34479965

Voss M, Kotrba J, Gaffal E, Katsoulis-Dimitriou K, Dudeck A. 2021. Mast cells in the skin: defenders of integrity or offenders in inflammation? Int J Mol Sci. 22:4589. IF: 4,556 PMID:33925601

Zimmermann S, Costa MBW, Mathew A, Krishnan S, Schneider JG, Roomp K, Isermann B, Biemann R. 2021. Osteocalcin is independently associated with C-reactive protein during lifestyle-induced weight loss in metabolic syndrome. Metabolites. 11:526. IF: 4,754 PMID: 34436467



Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH. 2020. Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 318:L149-L164. IF: 3,78 PMID:31693390

Dubiel W, Chaithongyot S, Dubiel D, Naumann M. 2020. The COP9 signalosome: a multi-DUB complex. Biomolecules 10:1082. IF: 4,082 PMID:32708147

Jorde I, Hildebrand CB, Kershaw O, Lücke E, Stegemann-Koniszewski S, Schreiber J. 2020. Modulation of allergic sensitization and allergic inflammation by Staphylococcus aureus enterotoxin B in an ovalbumin mouse model. Front Immunol. 11:592186. IF: 5,085 PMID:33193436

Katsoulis-Dimitriou K, Kotrba J, Voss M, Dudeck J, Dudeck A. 2020. Mast cell functions linking innate sensing to adaptive immunity. Cells. 9:2538. IF: 4,366 PMID:33255519

Madhusudhan T, Ghosh S, Wang H, Dong W, Gupta D, Elwakiel A, Stoyanov S, Al-Dabet MM, Krishnan S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi I, Rana R, Zeng-Brouwers J, Moeller MJ, Schaefer L, Esmon CT, Kohli S, Reiser J, Rezaie AR, Ruf W, Isermann B. 2020. Podocyte integrin-β3 and activated protein C coordinately restrict RhoA signaling and ameliorate diabetic nephropathy. J Am Soc Nephrol. 31:1762-1780. IF: 9,274 PMID:32709711

Morgenroth R, Reichardt C, Steffen J, Busse S, Frank R, Heidecke H, Mertens PR. 2020. Autoantibody formation and mapping of immunogenic epitopes against cold-shock-protein-YB-1 in cancer patients and healthy controls. Cancers. 12:3507. IF: 6,126 PMID:33255653

Nowak A, Relja B. 2020. The impact of acute or chronic alcohol intake on the NF-κB signaling pathway in alcohol-related liver disease. Int J Mol Sci. 21:9407. IF: 4,556 PMID:33321885

Wu Q, Jorde I, Kershaw O, Jeron A, Bruder D, Schreiber J, Stegemann-Koniszewski S. 2020. Resolved influenza a virus infection has extended effects on lung homeostasis and attenuates allergic airway inflammation in a mouse model. Microorganisms. 8:1878. IF: 4,167 PMID:33260910

Xu B, Chandrasekar A, Olde Heuvel F, Powerski M, Nowak A, Noack L, Omari J, Huber-Lang M, Roselli F, Relja B. 2020. Ethanol intoxication alleviates the inflammatory response of remote organs to experimental traumatic brain injury. Int J Mol Sci. 21:8181. IF: 4,556 PMID:33142949



Brandt S, Ewert L, Scurt FG, Reichardt C, Lindquist JA, Gorny X, Isermann B, Mertens PR. 2019. Altered monocytic phenotypes are linked with systemic inflammation and may be linked to mortality in dialysis patients. Sci Rep. 9:19103. IF: 3,998 PMID:31836803


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