RTG 2408 - Maladaptive processes across physiological barriers in chronic diseases

Behzad Amirkhizi

Associated member

Behzad Amirkhizi

Institute of Experimental Internal Medicine
Medical Doctor Project 8
Medical Doctor Project 8

MD8: H. pylori-induced stress response signaling in the gastric mucosa

BA

Behzad Amirkhizi

MD Student

                                

MN_n

Michael Naumann

Project Leader

 

 

 

The human pathogen Helicobacter pylori colonises the gastric epithelium and is a risk factor for gastric diseases including gastric cancer. The disease-promoting microenvironment involves, e.g. subepithelial fibroblasts. In order to characterize maladaptive responses at the epithelial gastric barrier we plan to study the H. pylori induced stress response signaling including p38, JNK and IKK activity and their role in cell survival. These studies will scrutinize the role of transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF‑kB) and activator protein 1 (AP-1) (cooperation Project P1-2 and Project 11-2). The role of stress response signaling for maladaptive processes in the gastric microenvironment will be investigated by co-culture of gastric carcinoma cells (NCI-N87) or gastric monolayer organoids, and fibroblasts in the Boyden chamber. Factors relevant for the maladaptation will be identified in the secretome of the cells (cooperation Associated Project 9 and Project 12-2).
MD08

H. pylori-induced stress response signaling in the gastric mucosa. The studies in gastric carcinoma cells (NCI-N87) or gastric monolayer organoids address the role of stress response signaling (p38, JNK, IKK) in H. pylori-associated apoptotic cell death. Maladaptive processes in the gastric microenvironment are investigated by co-culture of NCI-N87 cells or gastric monolayer organoids and fibroblasts in the Boyden chamber. Factors relevant for the maladaptation will be identified in the secretome of the cells.

Photos: by UMMD, Melitta Schubert/Sarah Kossmann

Last Modification: 13.03.2024 - Contact Person:

Sie können eine Nachricht versenden an: Webmaster
Sicherheitsabfrage:
Captcha
 
Lösung: